I didn't see Bill Maher's first show of the season, but here's a link to video in which guest Christopher Hitchens flips off the audience and tells them "Fuck you."

His point is that equivalence between Bush and Ahmadinejad is stupid and frivolous. And if you can't tell the difference, then you're not to be taken seriously.

I've seen Hitchens berate an audience before, but never tell them to fuck themselves. Good stuff.